November 25, 2012


Cellular damage occurs repeatedly every day 

  • Sunlight, toxins, chemicals, infections and other irritants damage cells every day
  •  Cuts, scrapes, blows and other minor injuries cause damage to millions of cells and tissues that must be regenerated and replaced
  • Even exercise and exertion can damage cells, causing tenderness (strain) and muscle aches

How does the body recognize damage?

  •  When cells are damaged the natural balanced chemistry inside the cell is disturbed, causing a shift in healthy metabolism and oxidative stress results
  • Oxidative Stress is the natural build-up of oxidant molecules, including free radicals, in the liquid environment inside cells
  • Oxidative stress is the condition that sends up red flags to neighboring healthy cells that cells have been damaged in their neighborhood

How does the body repair damage?

  • The immune system is activated by oxidative stress to kill the harmful invading organisms
  • The immune system also kills and dissolves damaged cells that cannot be repaired (swelling and redness mark this stage)
  • The immune system uses oxidative “bullets” to kill invading organisms and dissolve damaged cells and foreign materials

How does the body regenerate tissues?

  • Healthy balanced chemistry is restored after all invading organisms are dead and damage is cleaned up (the red flags are turned off)
  • Restoration of this chemical balance turns off swelling and redness and stimulates neighboring healthy cells to divide and fill in the missing cells and tissue
  • Healthy cells still continue to divide and multiply until the gap has been filled in with healthy new cells

How does the body maintain a healthy chemical balance?

  • Antioxidants, in conjunction with “Reductants,” neutralize stray oxidants in order to protect healthy cells
  • Antioxidants keep excess oxidants in check, neutralizing them and maintaining correct chemical balance
  • Cells produce antioxidants and deploy them to protect vulnerable areas inside and outside of the cell

How are Reductants and oxidants made?

  • Reductants and oxidants are “reactive molecules” that are formed naturally in the cell, made from the simple atoms in the salt water that fill and surround the cells
  • The Mitochondria inside the cells produce these reactive molecules both oxidants and Reductants and also produce the fuel used to energize the cell (ATP)
  • The Reductants pair up with anti-oxidants to protect the cell from excess reactive oxygen and toxins
  • The oxidants are the weapon of choice used by the immune system to destroy invading organisms
  • Oxidants are also “red flags’ that call for help when the cell is damaged or under attack

Why is a healthy chemical balance of “reactive molecules” important?

  • Too many oxidants in the cells or blood causes damage and aging to all tissues
  • An incorrect balance of Reductants and oxidants can cause the immune system to attack healthy cells , inflame tissues and slows down the healing process
  • Too few oxidants will remove the “red flags” and allow damaged, infected and malfunctioning cells (those that should be flagged and destroyed by the immune system) to thrive, divide and spread the damage

How can I help maintain a healthy chemical balance?

  • Supplement the raw materials the body needs to support the immune system
  • Raw, green vegetables, juices and herbs
  • Or, anti-oxidants and vitamin supplements
  • Use products that have the correct balance of Reductants that enhance the action of the anti-oxidants
  • Maintain a proactive and healthy attitude – mental attitude measurably helps balance the body’s chemistry

1. H. Kiura, et al., "Bactericidal activity of electrolyzed acid water from solution containing sodium chloride at low concentration, in comparison with that at high concentration", J. Microbio. Methods, v49, p285-93 (2002)
2. I.J. Wilk, RS Altmann and JD Berg, “Antimicrobial Activity of Electrolyzed Saline Solutions”, The Science of the Total Environment, v63 p191-197, Elsevier Science Pub (1987)
3. Emer P. Reeves, “Reassessment of the microbicidal activity of reactive oxygen species and hypochlorous acid with reference to the phagocytic vacuole of the neutrophil granulocyte”, J of Medical Microbio, v52, p643-651 (2003)
4. Babior BM, “Oxygen-dependent microbial killing by phagocytes (first of two parts)”, N Engl J Med v298, p659-68 (1978)
5. Sung-Hoon Lee and Bong-Kyu Choi, “Antibacterial Effect of Electrolyzed Water on Oral Bacteria”, J Microbio v44,4 p417-22 (Aug 2006)
6. Balazs K Rada et al., “Dual role of phagocytic NADPH oxidase in bacterial killing”, Blood v104,9 p2947-53 (1 Nov 2004)
7. H. Tanaka, et al., "Antimicrobial activity of superoxidized water", J. Hospital Infection, v34(1), p43-49 (Sep 1996)
8. Christine C. Winterbourn, “Modeling the Reactions of Superoxide and Myeloperoxidase in the Neutrophil Phagosome, Implications for Microbial killing”, The J of Bio Chem v281,52 p39860-69 (29 Dec 2006)
9. Kokichi Hanaoka, “The mechanism of enhanced antioxidant effects against superoxide anion radicals of reduced water produced by electrolysis”, Biophys Chem v107,1 p17-82 (Jan 2004)
10. Kokichi Hanoka, “Antioxidant effects of reduced water produced by electrolysis of sodium chloride solutions”, J Appl Electrochem, 31: 1307-1313 (2001)
11. Shirahata S, “Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage”, Biochem Biophys Research Comm, v234(1), p269-74 (May 8,1997)
12. Peter H. Proctor, “Free Radicals and Disease in Man (A review)”, Physiol Chem and Phys and Med NMR, v16 p175-195 (1984)
13. Roy J. Soberman, “The expanding network of redox signaling: new observations, complexities, and perspectives”, J. Clin. Invest. v111, p571-574 (2003)
14. Chandan K. Sen, “The general case for redox control of wound repair”, Wound Rep Reg, v11 p431-438 (2003)
15. S. Roy, et al., "Dermal wound healing is subject to redox control", Mol Ther., v13(1), p211-220 (Jan 2006)
16. Huang KC, “Reduced hemodialysis-induced oxidative stress in end-stage renal desease patients by electrolyzed reduced water”, Kidney International v62(2), p704-14 (Aug 2003)
17. Communications to the Editor, “Rate of Reaction of Superoxide Radical with Chloride-Containing Species”, J Phys Chem v84 p555-7 (1980)
18. Oxygen Radicals in Biology and Medicine, Plenum Press, ed. Michael G. Simic, et al. (1987) [Book based on papers presented at the “Fourth International Congress on Oxygen Radicals (4-ICOR),” held June 27 – July 3, 1987 at the University of California, La Jolla.]
19. Oxygen Radicals in Biology and Medicine, Plenum Press, ed. Michael G. Simic, et al. (1987) [Book based on papers presented at the “Fourth International Congress on Oxygen Radicals (4-ICOR),” held June 27 – July 3, 1987 at the University of California, La Jolla.]
20. Michael G. Simic and Karen A. Taylor, “Introduction to Peroxidation and Antioxidation Mechanisims”. Pg 1
21. Donald T Sawyer, “The Thermodynamics for Dioxygen Species (O2, O2-*, HOO*, HOOH and HOO-) and Monooxygen species (O, O-*, *OH and OH-) in water and Aprotic Solvents”. Pg. 11
22. John Biaglow, et al., “Cellular Protection Against Damage by Hydroperoxides”, Pg. 567
23. Igor B. Afans’ev, Superoxide ION Chemistry & Biological Implications Vol I,II, CRC Press (1989)
24. The Biology and Chemistry of Active Oxygen, Elsevier, Volume 26, ed. J.V. and W.H. Bannister, (1984)
25. R.J.P. Williams, “An Introduction to the Biological Chemistry of Oxygen”, Pg 136.
26. J.V. Bannister and G. Rotilio, “A Decade of Superoxide Dismutase Activity”, Pg. 146
27. B.M. Babior, “Superoxide and Oxidative Killing by Phagocytes”, Pg. 190
28. W.H. Bannister, “Superoxide Dimutase and Disease”, Pg. 208
29. Antioxidant and Redox Regulation of Genes, Academic Press, ed. Chandan K. Sen (2000)
30. Lars-Oliver Klotz, et al., "Signaling by Singlet Oxygen in Biological Systems", Pg. 3
31. Crawford, Suzuki and Davies, "Redox Regulation of Gene Expression", Pg. 21
32. Giron-Calle and Forman, "Cell Ca2+ in Signal Transduction: Modulation in Oxidative Stress", Pg. 106
33. P.A. Baeuerle, "Reactive Oxygen Species as Costimulatory Signals of Cytokine-Induced NF-kappaB Activation Pathways", Pg. 181
34. V.Goossens, et al., "Role of Reactive Oxygen Species in Tumor Necrosis Factor Toxicity", Pg. 245
35. S. Roy, C.K. Sen, et al., "Redox Regulation of Cell Adhesion Processes", Pg. 266
36. N. Maulic and D.K. Das, "Redox Regulation of Ischemic Adaptation", Pg. 492
37. W.C. Orr and R.S. Sohal, "Oxidative Stress as a Governing Factor in Physiological Aging", Pg. 517
38. L.S. Terada, "Specificity in reactive oxidant signaling: think globally, act locally (mini review)", J. of Cell Biology, v174(5), p615-23 (Aug 2006)
39. Joseph I. Kourie, “Interaction of reactive oxygen species with ion transport mechanisms (an invited review)”, Am J Physiol v275 pC1-C24 (1998)
40. H.T.F. Facundo, et al., "Mitochondrial ATP-sensitive K+ channels are redox-sensitive pathways that control reactive oxygen species production", Free Radical Biology and Medicine, v42(7), p1039-48 (Apr 2007)
41. A. Yu. Andreyev, et al., “Mitochondrial Metabolism of Reactive Oxygen Species”, Biochemistry (Moscow), v20(2), p 246-64 (2005) []
42. A.F. Jalbout, X.H. Li and M Solimannejad, "Thermochemical stability of the HO2-HOCl complex", Chem. Phys. Letters, v420 (1-3), p 204-08 (Mar 2006)
43. M. Solimannejad, I. Alkorta, J. Elguero, "Stabilities and Properties of O3-HOCl complexes; A computational study", Chem. Phys. Letters, v449, p 23-27 (2007)
44. D.C. Phillips, et al., "Sphingosine-Induced Apoptosis in Rhabdomyosarcoma Cell Lines Is Dependent on Pre-Mitochondrial Bax Activation and Post-Mitochondrial Caspases", Cancer Res, v67(2), p756-64 (Jan 2007)
45. C.M. Cruz, et al., "ATP Activates a ROS-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages", The J. or Bio. Chem., v282(5), p2871-79 (Feb 2007)
46. B.J. Hawkins, M. Madesh, C.J. Kirkpatrick, A.B. Fisher, "Superoxide Flux in Endothelial Cells via the Chloride Channel-3 Mediates Intracellular Signaling", Molec. Bio. of the Cell, v18, p2002-2012 (Jun 20

Popular Posts